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Combating Cancer

Liver Cancer | HCC Surveillance & Treatment

Known also as the silent killer, chronic liver disease is big, complex and accelerating. Driven by viral infection, diet and lifestyle, 1.5 billion people worldwide are in jeopardy. Of these, 80% of new cases and 72% of total deaths occur in Asia alone.

Lung Cancer

Lung cancer is one of the most common forms of cancer, with 1.3 million people being diagnosed every year in APAC. Majority of these cases are diagnosed at late stages, when survival rates are low.

Precision Oncology

Cancer is the leading cause of death worldwide, responsible for nearly 1 in 6 deaths in 2020, majority of which coming from Asia. With an ageing population, and emerging factors like diet and environment, the burden of cancer is only projected to increase.

Cervical Cancer

Cervical cancer has a high disease burden in APAC, with 50% of global cases and 60% of global deaths occuring in APAC. Almost all (99%) cervical cancer cases are linked to infection with high risk human papillomavirus, which is easily preventable through vaccination, advances in screening, and appropriate treatment. However, barriers still exist that prevent some women from being screened for cervical cancer.

Recent Articles

13 September 2024

Empowering Precision Oncology: Leveraging digital solutions to facilitate molecular tumour board meetings and patient care management

19 August 2024

Pioneering Innovations in HCC Detection for Enhance Patient Outcomes – Chang Gung Memorial Hospital

19 August 2024

Strategic Efficiencies: Evaluating Cost-Effectiveness of Biomarker-Based HCC Surveillance

30 July 2024

A Bold Stride Forward for Liver Health: Thailand’s Nationwide HBV Screening and EZ Liver Clinic

27 June 2024

Cost-Utility of Novel Biomarker-Based Strategies for Hepatocellular Carcinoma (HCC) Surveillance in Thailand

13 May 2024

No woman left behind: Increasing access to testing for cervical cancer elimination

13 May 2024

Advancing women’s health: Project Teal drives cervical cancer screening in Hong Kong

13 May 2024

Impact and opportunity: the case for investing in women’s cancers in Asia Pacific

13 May 2024

WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention

13 May 2024

Recommendations for Use of p16/Ki67 Dual Stain for Management of Individuals Testing Positive for Human Papillomavirus

12 April 2024

Urgent Global Need for PIVKA-II and AFP-L3 Measurements for Surveillance and Management of Hepatocellular Carcinoma

8 April 2024

Turning the Tide Against Hep B and HCC: Insights from New Zealand’s National Screening and Surveillance Program

20 March 2024

Development and Clinical Validation of a Novel Algorithmic Score (GAAD) for the Detection of Early-stage Hepatocellular Carcinoma

This study aims to establish and train the algorithm coefficients, and clinically validate the performance of the GAAD algorithm in differentiating HCC and benign chronic liver…

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5 March 2024

Early-stage hepatocellular carcinoma screening in patients with chronic hepatitis B in China: a cost–effectiveness analysis

13 February 2024

The Pursuit for Better Patient Outcomes – Innovating HCC Management at Siriraj Hospital

7 November 2023

Value and Challenges for Precision Oncology Realisation in Real World Practice

In this interview, Prof Chiu discusses the value of NGS testing to identify lung cancer driver mutations to detect and treat lung cancer early. He also…

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2 October 2023

Patient-centric and ecosystem insights into hepatocellular carcinoma across Asia-Pacific – LEAP

In this white paper, insights on the liver ecosystem are uncovered, with the intention of facilitating action among various stakeholders to reduce liver cancer incidence and…

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18 September 2023

Advancing Liver Health Ecosystem for Improve Patient Outcomes: A Hong Kong Perspective

In this interview with Prof Yuen, Chief of Division of Gastroenterology and Hepatology in the University of Hong Kong, explore Hong Kong's current liver health ecosystem,…

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23 August 2023

NGS and precision oncology in Australia: insights from Profs Peter Gibbs and Svetlana Cherepanoff

In this article, Prof Peter Gibbs and Prof Svetlana Cherepanoff discuss the issues surrounding the clinical integration of NGS in Australia.

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23 August 2023

NGS and precision oncology in Taiwan: insights from Dr Jan-Gowth Chang and Dr Jason CH Hsieh

NGS and digital applications for oncology management can help improve early cancer detection and prevention, reducing human and economic costs of the cancer. In this article,…

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23 August 2023

Building modern hepatocellular carcinoma surveillance programmes: taking steps to address a leading cause of liver cancer death in Asia

In this whitepaper, HCC surveillance programs in Asia were analysed. The learnings from well established HCC surveillance programs, as well as the challenges in areas that…

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18 August 2023

NGS and precision oncology in India: insights from Dr Amit Rauthan

In this article, Dr Amit Rauthan shares insights on the challenges and opportunities for greater NGS adoption in India.

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18 August 2023

Clinical and Economic Impact of Upfront Next-Generation Sequencing for Metastatic NSCLC in East Asia

This study aimed to evaluate the economic impact of upfront NGS compared to testing modalities in East Asian patients with mNSCLC, by using Hong Kong as…

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17 August 2023

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

This study proposes a unified framework to classify targets for precision cancer medicine based on clinical evidence of utility, to aid oncologists in prioritising potential targets…

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17 August 2023

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11 August 2023

The impact of the multi-disciplinary molecular tumour board and integrative next generation sequencing on clinical outcomes in advanced solid tumours

The integration of next-generation sequencing (NGS) comprehensive gene profiling (CGP) into clinical practice is playing an increasingly important role in oncology. Therefore, the HKU-HKSH Multi-disciplinary Molecular…

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28 July 2023

Get the latest updates in the liver space with our HCC detection (HD) expert pack

23 June 2023

Leading the Way for HCC Surveillance and Diagnosis: Prof. Henry LY Chan

In this video, Prof Henry LY Chan, Deputy Chief Manager at Union Hospital Hong Kong, discusses how PIVKA-II can complement AFP and Ultrasound in assisting clinicians…

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19 June 2023

Serum PIVKA-II and alpha-fetoprotein at virological remission predicts hepatocellular carcinoma in chronic hepatitis B related cirrhosis

This study aimed to investigate the role of serum PIVKA-II and alpha-fetoprotein in predicting HCC and mortality in cirrhotic CHB patients at virological remission following NA…

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19 June 2023

Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis

This meta-analysis aims to provide insight on the efficacy of using combined biomarkers, AFP, AFP-L3, DCP, DKK-1, and GP73, for clinical decision-making for patients with HCC.…

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19 June 2023

The prognostic values of serum markers in hepatocellular carcinoma after invasive therapies based on real-world data

The purpose of this study is to evaluate the prognostic values of serum markers in HCC, with retrospective data. Li B, Liu A, Wen Y, Yang…

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19 June 2023

The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients

This study aims to investigate the diagnostic role of PIVKA-II alone or in combination with AFP in Chinese HCC patients. Xu F, Zhang L, He W,…

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19 June 2023

HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis

This systematic review and meta-analysis of cohort studies of patients with cirrhosis aimed to evaluate the benefit and harms of HCC surveillance in patients with cirrhosis.…

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19 June 2023

Efficacy analysis of combined detection of 5 serological tumor markers including MIF and PIVKA-II for early diagnosis of primary hepatic cancer

The aim of this study was to investigate the efficacy of combined detection of 5 serological tumor markers including macrophage migration inhibitory factor (MIF) and abnormal…

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31 May 2023

APASL 2023 Taiwan Congress Report

Catch up on the highlights of APASL 2023 with this congress report, covering session on hepatitis B, hepatitis C, hepatocellular carcinoma, and fatty liver disease.

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Cancer genomic testing | Jennifer’s story

Comprehensive genomic profiling (CGP) is a method of cancer genomic testing used to reveal the unique set of mutations within the cancer’s DNA which determine how…

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22 May 2023

NGS and precision oncology in Hong Kong: insights from Dr Lam Tai-Chung

In this article, Dr Lam Tai-Chung shares how his institution has had first-hand experience of landmark cases and outstanding treatment responses from using NGS in seemingly…

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22 May 2023

Next-generation sequencing (NGS) drives precision oncology in Singapore

In this article, Dr David Tan discusses the potential of NGS in Singapore, where the adoption of this technology is only just beginning to take root.

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22 May 2023

NGS and precision oncology in South Korea: insights from Prof Kim Jee-Hyun

In this article, Prof Jee Hyun Kim explains her clinical experiences of NGS, and how she sees it evolving within South Korea’s innovative healthcare ecosystem.

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22 May 2023

Breaking barriers to precision oncology implementation with digital solutions

While precision oncology has shown great promise, there are still barriers to its implementation, such as data fragmentation, staff shortages and time, funding, and lack of…

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19 May 2023

Unlocking the Value of Quality Next-Generation Sequencing in APAC

This whitepaper shares recommendations on ensuring standardization and quality of NGS across the region, to realize the potential of NGS and establish more effective and market-appropriate…

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19 May 2023

Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with locally-advanced unresectable non-small-cell lung cancer: a KSMO-ESMO initiative endorsed by CSCO, ISMPO, JSMO, MOS, SSO and TOS

This guideline aims to adapt the ESMO 2017 guidelines to take into account potential differences related to ethnicity, cancer biology and standard practices associated with the…

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19 May 2023

National Comprehensive Cancer Network (NCCN) guidelines for lung cancer

The NCCN Guidelines are a comprehensive set of guidelines detailing the sequential management decisions and interventions to assist in the decision-making process of individuals involved in…

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19 May 2023

Expert Consensus Recommendations on Biomarker Testing in Metastatic and Non metastatic NSCLC in Asia

This report provides consensus recommendations for NSCLC biomarker testing from Asian lung cancer experts for clinicians working in Asia to improve patient care. Biomarker testing approaches…

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19 May 2023

Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group

These recommendations provide a critical guidance from NGS panel testing to final treatment decision based on MTB discussion.

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19 May 2023

Hepatocellular carcinoma surveillance and the emerging role of biomarker-based models

A/Prof Simone Strasser recently published an independent commentary in the Australian Medical Research and Journal "Research Review", covering at length topics such as non-alcoholic liver disease…

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19 April 2023

Clinical Utility of Protein Induced by Vitamin K Absence-II in Patients with Hepatocellular Carcinoma

This study aimed to assess the clinical utility of PIVKA-II in addition to AFP in patients with HCC. Bhatti ABHH, Naz K, Abbas G, Khan NY,…

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12 April 2023

PIVKA-II: Confidence in HCC surveillance and diagnosis: Prof. Ming-Lung Yu

In this video, Prof Ming-Lung Yu, Chair Professor of Hepatology at Kaohsiung University Medical Hospital, discusses how PIVKA-II can complement AFP and Ultrasound in assisting clinicians…

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17 March 2023

Utility of Combining PIVKA-II and AFP in the Surveillance and Monitoring of Hepatocellular Carcinoma in the Asia-Pacific Region

A panel of 17 experts from Asia-Pacific, gathered to discuss and reach a consensus on the clinical usefulness and value of PIVKA-II for the surveillance and…

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17 March 2023

Evaluation of the diagnostic accuracy of des-gamma-carboxy prothrombin and alpha-fetoprotein alone or in combination for hepatocellular carcinoma: A systematic review and meta-analysis

This article aims to clarify the diagnostic value of DCP (PIVKA-II) and AFP in patients with different risk of HCC development (etiology, ethnicity, and various stages…

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17 March 2023

A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma

This study reanalyzes the related studies of 11 blood biomarkers of HCC, and compares the diagnostic value of these biomarkers for HCC systematically. Pang BY, Leng…

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14 March 2023

Surveillance of Hepatocellular Cancer Among Hepatitis B and Cirrhosis Patients Using Protein Induced by Vitamin K Absence-II (PIVKA-II): A Cost-Utility Analysis for Hong Kong as an Example of Endemic Regions

This study evaluates the cost-effectiveness of serological tests or ultrasound alone versus their joint use with or without multivariate index algorithm for HCC screening in chronic…

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14 March 2023

Biomarkers for the Early Detection of Hepatocellular Carcinoma

This review highlights promising candidate biomarkers and biomarker panels that have completed phase II evaluation for the early detection of HCC. Parikh ND, Mehta AS, Singal…

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14 March 2023

Cost-effectiveness Analysis of GAAD algorithm on Hepatocellular Carcinoma Screening in Patients with Chronic Hepatitis B in China

This study evaluates the cost-effectiveness of serological tests or ultrasound alone versus their joint use with or without multivariate index algorithm for HCC screening in chronic…

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14 March 2023

Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

These latest guidelines recommend evidence-based management of HCC and are considered suitable for universal use in the Asia-Pacific region, which has a diversity of medical environments.…

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14 March 2023

Impact of PIVKA-II in diagnosis of hepatocellular carcinoma

This study was designed to investigate the potential role of PIVKA-II as a diagnostic, non-invasive marker for HCC at its early stages and to assess its…

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14 March 2023

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma

This white paper, which was developed by a group of experts in biomarker development, provides a framework on best practices to design, execute, and interpret biomarker…

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14 March 2023

Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)

Since the publication of Guidelines for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition), additional high-quality evidence has emerged with relevance to the diagnosis, staging,…

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14 March 2023

Clinical practice guidelines for hepatocellular carcinoma: The Japan Society of Hepatology 2017 (4th JSH-HCC guidelines) 2019 update

The 4th version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, and published in October 2017 in Japanese. New…

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14 March 2023

Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis

Society guidelines differ in their recommendations for surveillance to detect early-stage hepatocellular carcinoma (HCC) in patients with cirrhosis. This study compared the performance of surveillance imaging,…

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14 March 2023

Diagnostic challenges in primary hepatocellular carcinoma: case reports and review of the literature

HCC diagnosis can be particularly challenging in some cases and the obtained results seem ambiguous, resulting in a long-term and delayed diagnostic process.This paper presents three…

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14 March 2023

Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma

This study aims to determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein (AFP) and prothrombin induced by vitamin K absence-II (PIVKA-II) in…

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14 March 2023

Diagnostic value of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage HBV related hepatocellular carcinoma

This study aims to evaluate the diagnostic efficacy of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage hepatitis virus B…

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13 March 2023

Hepatocellular carcinoma surveillance: current practice and future directions

This review article provides a comprehensive overview of the indications and rationale for HCC surveillance, currently available surveillance methods and their utilization, effectiveness, and limitations, as…

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13 March 2023

Protein induced by vitamin K absence or antagonist-II versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis

PIVKA-II has been extensively studied as a biomarker in HCC. However, its diagnostic capability varies across HCC studies. This study aimed to compare the performance of…

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13 March 2023

Diagnostic value of serum PIVKA-II levels for BCLC early hepatocellular carcinoma and correlation with HBV DNA

This study aims to determine the clinical value of serum Prothrombin induced by vitamin K absence-II (PIVKA-II) in early hepatocellular carcinoma (HCC), and to explore its…

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13 March 2023

Leading the Way for HCC Surveillance and Diagnosis: Dr Bao Toan Nguyen

In this video, Dr Bao Toan Nguyen from MEDIC-LAB Ho Chi Minh discusses how PIVKA-II can complement AFP in assisting clinicians in the early detection and…

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9 December 2022

Liver Disease in Asia Pacific: Insights from Prof Pierce Chow

In this Q&A, Prof Pierce Chow of the National Cancer Centre Singapore discusses the epidemiology of liver disease in Asia Pacific; key considerations around the clinical…

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9 December 2022

Liver Disease and Patient Advocacy in Taiwan: Q&A with Prof Yang Pei-Ming

Liver disease is a serious public health issue in Taiwan. The Liver Disease Prevention and Treatment Research Foundation, Taiwan, is one of Asia’s most active and…

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9 December 2022

Liver Cancer in Japan: Dr Shun Kaneko on HCC Screening and Surveillance

Japan is a global leader in hepatocellular carcinoma (HCC) surveillance, with an effective programme that enables early-stage carcinomas detection. Yet unmet needs continue to affect the…

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9 December 2022

HCC in Thailand: Dr Terachai Songkiatkawin on Improving Liver Cancer Diagnostics and Treatment

More than 27,000 patients in Thailand are found to have liver cancer each year, making it the most-frequently diagnosed cancer in the country. With emerging risk…

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9 December 2022

Tackling HCV in Punjab: local experts share strategies for success

Punjab is one of Pakistan’s largest provinces and has a particularly high HCV prevalence rate of roughly 9%, compared to 5.4% for Pakistan’s total population. Hear…

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9 December 2022

Strengthening healthcare systems through the critical role of diagnostics

In line with the WHO Essential Diagnostics List (EDL) and Lancet Commission efforts, the Asia Pacific Medical Technology Association and its members recently came together to…

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9 December 2022

Pakistan’s national HCV elimination programme: insights from Dr Huma Qureshi

In 2019, Pakistan announced a nationwide programme to scale up HCV prevention, testing and treatment. Hear from gastroenterologist Dr Huma Qureshi, a key figure in Pakistan’s…

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9 December 2022

Hepatitis C: the patient journey from screening to diagnosis and treatment

An estimated 71 million people around the world are chronically infected with hepatitis C virus (HCV), with a large proportion currently being undiagnosed or diagnosed late.…

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9 December 2022

HCV screening in Egypt: key elements of a successful national screening programme

In 2018, the world’s largest HCV screening campaign was initiated in Egypt. Within 7 months following its initiation, 49.5 million people were screened; and 2.2 million…

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9 December 2022

HCV elimination in Sindh: insights from Prof Muhammad Sadik Memon and Dr Zaigham Abbas

The province of Sindh has one of the world’s highest rates of HCV infection and bears the second highest disease burden of both HBV and HCV…

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9 December 2022

HCV elimination in Pakistan: insights from Dr Zaigham Abbas

Pakistan has one of the world’s highest rates of HCV infection. Learn from Dr Zaigham Abbas, Head of Gastroenterology at Ziauddin University Hospital and President of…

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9 December 2022

HCV elimination in Northern Pakistan: Prof Aamir Khan on treating patients in KPK province and the Afghan borderlands

Pakistan has one of the world’s highest rates of HCV infection. It's no surprise that their healthcare systems face mounting pressure from HCV-related conditions. Learn from…

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9 December 2022

Future therapies for chronic Hepatitis B and the role of diagnostics

Hepatitis B is an important infectious disease problem in the APAC region. Learn from Prof Henry Chan, director of the Center for Liver Health at Chinese…

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9 December 2022

The clinical utility of Elecsys GAAD score in the diagnosis of hepatocellular carcinoma

The performance of Elecsys® GAAD score, which includes the parameters of gender, age, alpha-fetoprotein (AFP) and protein induced by Vitamin K absence or antagonists-II (PIVKA-II) in…

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9 December 2022

Performance evaluation of the Elecsys PIVKA-II and Elecsys AFP assays for hepatocellular carcinoma diagnosis

Prothrombin induced by vitamin K absence-II (PIVKA-II) is a serum biomarker linked to hepatocellular carcinoma (HCC), showing superiority to alpha-fetoprotein (AFP) for early disease detection. This…

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9 December 2022

Performance Evaluation of the Elecsys GAAD Assay for the Detection of Hepatocellular Carcinoma Across Different Disease Stages and Etiologies

The Elecsys® GAAD algorithm combines quantitative measurements of Elecsys PIVKA-II assay and Elecsys AFP assay, plus age and gender to generate a semi-quantitative result. This study…

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9 December 2022

Multimarker Panels for Detection of Early Stage Hepatocellular Carcinoma: A Prospective, Multicenter, Case-Control Study

This study systematically evaluates biomarkers mentioned in international guidelines and peer-reviewed literature for HCC surveillance and diagnosis, in order to identify combinations of biomarkers that display…

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9 December 2022

Elecsys PIVKA-II and Elecsys AFP assays demonstrate good clinical performance for hepatocellular carcinoma (HCC) diagnosis across different disease stages and aetiologies

This study evaluates the clinical performance of the new Elecsys PIVKA-II immunoassay and the previously launched Elecsys AFP assay (Roche Diagnostics) to aid in the diagnosis…

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9 December 2022

Clinical evaluation of Elecsys PIVKA-II for patients with advanced hepatocellular carcinoma

Prothrombin induced by vitamin K absence-II (PIVKA-II) was reported as a diagnosis and prognosis marker for hepatocellular carcinoma (HCC). This prospective study aims to comparatively verify…

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9 December 2022

APACMed White Paper – Strengthening Healthcare Systems Through the Critical Role of Diagnostics

Diagnostic technologies are used across the entire patient journey of multiple disease states, and provide the tools to prevent, detect, and monitor the required interventions. Despite…

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9 December 2022

Analytical performance and method comparison of the Elecsys PIVKA-II immunoassay as an aid in diagnosis of hepatocellular carcinoma (HCC)

This study evaluates the analytical performance of the Elecsys PIVKA-II immunoassay to aid in HCC diagnosis, establish method-specific reference ranges in healthy individuals, and perform a…

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9 December 2022

A comparative analysis of Elecsys GALAD and Elecsys GAAD score to detect early-stage hepatocellular carcinoma in an international cohort

This study compared the clinical performance of the Elecsys GALAD (gender [sex], age, alpha-fetoprotein [AFP] Lens culinaris agglutinin-reactive fraction of AFP [AFP-L3] and protein-induced by vitamin…

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8 December 2022

My greatest hope | Mr Yan’s liver cancer story

Mr Yan was diagnosed with hepatocellular carcinoma (HCC) in 2018. He was a healthy, active person as a competitive skier, and his diagnosis was completely unexpected.…

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8 December 2022

Hepatocellular carcinoma – the ‘silent killer’ disease infographic

Chronic liver disease (CLD) is on the rise. CLD can progress to Hepatocellular Carcinoma (HCC), a type of liver cancer. What are the risk factors for…

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8 December 2022

Hepatocellular carcinoma – the ‘silent killer’ | Part 2

How did Taiwan halve the incidence of hepatocellular carcinoma (HCC) in a decade? HCC is the primary form of liver cancer, with 72% of cases diagnosed…

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8 December 2022

Hepatocellular carcinoma – the ‘silent killer’ | Part 1

Do you know what can cause hepatocellular carcinoma, the primary form of liver cancer? In Asia, contaminated food has historically been linked with the disease and…

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8 December 2022

Liver cancer: the global impact

Hepatocellular carcinoma numbers continue to rise globally, due to major risk factors such as Hepatitis B and C, and fatty liver disease. Hear Liver Patients International’s…

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8 December 2022

Breaking the link between chronic liver disease and liver cancer

Millions of people are living with chronic liver disease. Can the link between chronic liver disease and liver cancer be broken through partnership?

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