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The impact of the multi-disciplinary molecular tumour board and integrative next generation sequencing on clinical outcomes in advanced solid tumours

Quick Summary

The integration of next-generation sequencing (NGS) comprehensive gene profiling (CGP) into clinical practice is playing an increasingly important role in oncology. NGS CGPs have been incorporated into clinical practice to improve patient outcomes by identifying actionable drug targets. To integrate NGS CGPs and faciliate the implementation of precision medicine into clinical practice, multi-disciplinary Molecular Tumour Boards (MTBs) have been established, and enable the timely referral of patients to genomically stratified clinical trials

In 2018, the University of Hong Kong (HKU) and Hong Kong Sanatorium & Hospital (HKSH) established the HKU-HKSH Multi-disciplinary MTB to advance precision oncology in Hong Kong. A multicenter retrospective clinical outcome analysis was conducted for patients with advanced solid cancers presented at the HKU-HKSH-MTB for review and treatment recommendations. The primary objective of the study was to demonstrate the survival impact of a comprehensively curated real-world retrospective MTB dataset to facilitate the management of patients with cancer in the era of precision oncology.

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